Filling in the missing data gaps will accelerate progress in improving protection against Novichoks and developing optimal therapy for treating poisoning casualties. Novichoks pose a severe threat due to their toxicity however, there is insufficient information about the identity of A-series nerve agents. The review includes data on treating poisoning caused by OPs which could be used as guidelines for the therapy in case of Novichok exposure and HAZMAT/CBRNE approaches. Novichok’s toxic action mechanism consists of the inhibition of acetylcholinesterase activity. They were surreptitiously created during the Cold War by the Soviet Union.
The tremendous toxicity of Novichoks is assumed to be several times greater than that of VX, whereas no published experimental research supports this. Novichoks-organophosphorus compounds belong to the nerve agents group, constituting the fourth generation of chemical warfare agents.
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